The Barcelona star staged the match to raise money for charity and brought a host of stars with him to the Atanasio Girardot stadium in Medellin, including the likes of Javier Mascherano, Pablo Aimar and Florent Malouda.
Brazil star Robinho was leading out the Rest of the World XI but they could do nothing to stop Messi and his friends running away with the victory.
Messi curled home the opener from just inside the area and was substituted with 20 minutes remaining to a standing ovasion.
Watch all the goals from the Lionel Messi & Friends v Rest of the World XI below...
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